Résumé
In the last two years, Cameroon has faced five waves of COVID-19, with its fourth wave of the B.1.1.529 Omicron variant in December 2021 and subsequently hosted the African Cup of Nation of Football Men's competition that gathered thousands of people from across the world in January 2022 with no increase in the number of cases/deaths. A fifth wave of BA.4, and BA.5 Omicron variants was seen in August 2022. The country as claimed 123 785 cases, 121 633 recovered and 1960 death by 30th September 2022. Despite a low vaccination coverage of 8.7% the country has seen a limited impact of COVID-19 as compared to the international prediction. The response of Cameroon focused in limiting the spread of the SARS-CoV-2 in the population, reducing the morbidity and mortality due to COVID-19 and limiting the socio economic impact of the COVID-19 in Cameroon. The contextualized Cameroonian response was based on an important epidemiologic surveillance relying on mass testing strategy and adaptative measure that ensure the continuity of the of planned mass gathering activities including hosting the African Cup of Nations of Football in the COVID-19 context and the continuity of education. While the COVID-19 has shown some weakness in the health system it has been an opportunity to show its resilience and the opportunity for strengthening the health system including the implementation of a genomic surveillance platform. The lessons learnt from COVID-19 including the importance of coordination through the Public Health Emergency Operating Centre will help the country to address the future public health emergencies and move toward cholera elimination by 2030.